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High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Overview of attention for article published in BMC Cancer, August 2014
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Title
High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients
Published in
BMC Cancer, August 2014
DOI 10.1186/1471-2407-14-604
Pubmed ID
Authors

Remco S Derr, Anneke Q van Hoesel, Anne Benard, Inès J Goossens-Beumer, Anita Sajet, N Geeske Dekker-Ensink, Esther M de Kruijf, Esther Bastiaannet, Vincent THBM Smit, Cornelis JH van de Velde, Peter JK Kuppen

Abstract

Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in relation with patient survival and tumor relapse in a retrospective cohort of 460 breast cancer patients. Additionally, we correlated expression levels with tumor differentiation and tumor cell proliferation.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Denmark 1 2%
Unknown 42 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Student > Bachelor 6 14%
Other 5 11%
Student > Ph. D. Student 4 9%
Student > Postgraduate 3 7%
Other 7 16%
Unknown 11 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 25%
Medicine and Dentistry 8 18%
Agricultural and Biological Sciences 7 16%
Chemistry 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 6 14%
Unknown 9 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2014.
All research outputs
#20,234,388
of 22,760,687 outputs
Outputs from BMC Cancer
#6,483
of 8,277 outputs
Outputs of similar age
#197,569
of 235,611 outputs
Outputs of similar age from BMC Cancer
#136
of 163 outputs
Altmetric has tracked 22,760,687 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,277 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,611 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.