Title |
CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models
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Published in |
Diabetology & Metabolic Syndrome, August 2014
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DOI | 10.1186/1758-5996-6-83 |
Pubmed ID | |
Authors |
Manoj Kumar Sadasivuni, Bobbili Madhusudhan Reddy, Jaideep Singh, Mammen O Anup, Venkategowda Sunil, Mudigere N Lakshmi, Sivakumaran Yogeshwari, Suni K Chacko, Talanki Lokesh Pooja, Anilkumar Dandu, Chandrashekaran Harish, Aralakuppe S Gopala, Shivakumar Pratibha, Baisani S Naveenkumar, Puttrevana M Pallavi, Mahesh Kumar Verma, Yoganand Moolemath, Baggavalli P Somesh, Marikunte V Venkataranganna, Madanahalli R Jagannath |
Abstract |
In addition to their role in growth, cellular differentiation and homeostasis Retinoid X Receptors (RXR) regulate multiple physiological and metabolic pathways in various organs that have beneficial glucose and lipid (cholesterol) lowering, insulin sensitizing and anti-obesity effects. Rexinoids, compounds that specifically binds and activate RXR, are therefore considered as potential therapeutics for treating metabolic syndrome. Apparently many of the rexinoids developed in the past increased triglycerides, caused hepatomegaly and also suppressed the thyroid hormone axis. The aim of this study is to evaluate CNX-013-B2, a potent and highly selective rexinoid, for its potential to treat multiple risk factors of the metabolic syndrome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 18% |
Student > Ph. D. Student | 6 | 18% |
Student > Doctoral Student | 4 | 12% |
Other | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 6 | 18% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 27% |
Medicine and Dentistry | 6 | 18% |
Chemistry | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Unspecified | 1 | 3% |
Other | 2 | 6% |
Unknown | 9 | 27% |