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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The role of glucagon on type 2 diabetes at a glance
|
|---|---|
| Published in |
Diabetology & Metabolic Syndrome, August 2014
|
| DOI | 10.1186/1758-5996-6-91 |
| Pubmed ID | |
| Authors |
Amélio F Godoy-Matos |
| Abstract |
The opposite effects of insulin and glucagon in fuel homeostasis, the paracrine/endocrine inhibitory effects of insulin on glucagon secretion and the hyperglucagonemia in the pathogenesis of type 2 diabetes (T2D) have long been recognized. Inappropriately increased alpha-cell function importantly contributes to hyperglycemia and reflects the loss of tonic restraint normally exerted by high local concentrations of insulin on alpha-cells, possibly as a result of beta-cell failure and alpha-cell insulin resistance, but additional mechanisms, such as the participation of incretin hormones in this response, have also been suggested. Three classes of drugs already available for clinical use address the abnormalities of glucagon secretion in T2D, namely, the GLP-1 receptor agonists (GLP-1RA), the inhibitors of dipeptidyl peptidase-4 (DPP-4i) and the amylin agonist pramlintide; it has been proposed that the glucagonostatic and insulinotropic effects of GLP-1RA equally contribute to their hypoglycemic efficacy. In this review, the control of glucagon secretion and its participation in T2D pathogenesis are summarized. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 25% |
| Canada | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iraq | 1 | <1% |
| Sweden | 1 | <1% |
| Russia | 1 | <1% |
| Unknown | 166 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 22% |
| Student > Master | 23 | 14% |
| Researcher | 20 | 12% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 22 | 13% |
| Unknown | 38 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 21% |
| Agricultural and Biological Sciences | 35 | 21% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Chemistry | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 20 | 12% |
| Unknown | 44 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2015.
All research outputs
#13,178,355
of 22,761,738 outputs
Outputs from Diabetology & Metabolic Syndrome
#267
of 662 outputs
Outputs of similar age
#109,129
of 236,033 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#4
of 21 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 662 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,033 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.