Title |
MMP-9 expression varies according to molecular subtypes of breast cancer
|
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Published in |
BMC Cancer, August 2014
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DOI | 10.1186/1471-2407-14-609 |
Pubmed ID | |
Authors |
Einas M Yousef, Muhammad R Tahir, Yves St-Pierre, Louis A Gaboury |
Abstract |
In 2014, breast cancer remains a major cause of mortality worldwide mostly due to tumor relapse and metastasis. There is currently a great interest in identifying cancer biomarkers and signalling pathways mechanistically related to breast cancer progression. Matrix metalloproteinase-9 (MMP-9) is a member of matrix degrading enzymes involved in cancer development, invasion and metastasis. Our objective was to investigate MMP-9 expression in normal human breast tissue and to compare it to that of breast cancer of various histological grades and molecular subtypes. We also sought to correlate MMP-9 expression with the incidence of metastasis, survival rates and relapse in breast cancer patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | <1% |
Unknown | 180 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 19% |
Student > Bachelor | 33 | 18% |
Student > Master | 18 | 10% |
Researcher | 16 | 9% |
Student > Postgraduate | 9 | 5% |
Other | 21 | 12% |
Unknown | 49 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 27 | 15% |
Agricultural and Biological Sciences | 26 | 14% |
Medicine and Dentistry | 20 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 9% |
Chemistry | 14 | 8% |
Other | 19 | 10% |
Unknown | 58 | 32% |