Title |
MiR-181b sensitizes glioma cells to teniposide by targeting MDM2
|
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Published in |
BMC Cancer, August 2014
|
DOI | 10.1186/1471-2407-14-611 |
Pubmed ID | |
Authors |
Yan-chang Sun, Jing Wang, Cheng-cheng Guo, Ke Sai, Jian Wang, Fu-rong Chen, Qun-ying Yang, Yin-sheng Chen, Jie Wang, Tony Shing-shun To, Zong-ping Zhang, Yong-gao Mu, Zhong-ping Chen |
Abstract |
Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete resection and resistance to radio-/chemotherapy. Therefore, it is worth investigating the molecular mechanisms involved in glioma drug resistance. MicroRNAs have been found to play important roles in tumor progression and drug resistance. Our previous work showed that miR-181b is involved in the regulation of temozolomide resistance. In the current study, we investigated whether miR-181b also plays a role in antagonizing the effect of teniposide. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 20% |
Student > Master | 4 | 16% |
Student > Doctoral Student | 3 | 12% |
Researcher | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Other | 4 | 16% |
Unknown | 3 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 40% |
Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Agricultural and Biological Sciences | 2 | 8% |
Immunology and Microbiology | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Other | 1 | 4% |
Unknown | 4 | 16% |