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MiR-181b sensitizes glioma cells to teniposide by targeting MDM2

Overview of attention for article published in BMC Cancer, August 2014
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Title
MiR-181b sensitizes glioma cells to teniposide by targeting MDM2
Published in
BMC Cancer, August 2014
DOI 10.1186/1471-2407-14-611
Pubmed ID
Authors

Yan-chang Sun, Jing Wang, Cheng-cheng Guo, Ke Sai, Jian Wang, Fu-rong Chen, Qun-ying Yang, Yin-sheng Chen, Jie Wang, Tony Shing-shun To, Zong-ping Zhang, Yong-gao Mu, Zhong-ping Chen

Abstract

Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete resection and resistance to radio-/chemotherapy. Therefore, it is worth investigating the molecular mechanisms involved in glioma drug resistance. MicroRNAs have been found to play important roles in tumor progression and drug resistance. Our previous work showed that miR-181b is involved in the regulation of temozolomide resistance. In the current study, we investigated whether miR-181b also plays a role in antagonizing the effect of teniposide.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 20%
Student > Master 4 16%
Student > Doctoral Student 3 12%
Researcher 3 12%
Student > Ph. D. Student 3 12%
Other 4 16%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 10 40%
Biochemistry, Genetics and Molecular Biology 5 20%
Agricultural and Biological Sciences 2 8%
Immunology and Microbiology 2 8%
Nursing and Health Professions 1 4%
Other 1 4%
Unknown 4 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2014.
All research outputs
#18,376,927
of 22,761,738 outputs
Outputs from BMC Cancer
#5,418
of 8,277 outputs
Outputs of similar age
#168,132
of 235,902 outputs
Outputs of similar age from BMC Cancer
#105
of 158 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,277 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,902 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 158 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.