Title |
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy
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Published in |
Skeletal Muscle, August 2014
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DOI | 10.1186/2044-5040-4-7 |
Pubmed ID | |
Authors |
Patrizia Pessina, Daniel Cabrera, María Gabriela Morales, Cecilia A Riquelme, Jaime Gutiérrez, Antonio L Serrano, Enrique Brandan, Pura Muñoz-Cánoves |
Abstract |
Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular dystrophy (DMD), which remains incurable. Substitution of muscle by fibrotic tissue also complicates gene/cell therapies for DMD. Yet, no optimal models to study muscle fibrosis are available. In the widely used mdx mouse model for DMD, extensive fibrosis develops in the diaphragm only at advanced adulthood, and at about two years of age in the 'easy-to-access' limb muscles, thus precluding fibrosis research and the testing of novel therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
Norway | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 3 | 2% |
United States | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 131 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 29 | 21% |
Student > Bachelor | 17 | 13% |
Researcher | 15 | 11% |
Student > Master | 15 | 11% |
Student > Doctoral Student | 9 | 7% |
Other | 22 | 16% |
Unknown | 29 | 21% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 4 | 3% |
Other | 14 | 10% |
Unknown | 32 | 24% |