Title |
Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar)
|
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Published in |
BMC Genomics, August 2014
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DOI | 10.1186/1471-2164-15-694 |
Pubmed ID | |
Authors |
You Song, Brit Salbu, Hans-Christian Teien, Lene Sørlie Heier, Bjørn Olav Rosseland, Tore Høgåsen, Knut Erik Tollefsen |
Abstract |
Uranium (U) is a naturally occurring radionuclide that has been found in the aquatic environment due to anthropogenic activities. Exposure to U may pose risk to aquatic organisms due to its radiological and chemical toxicity. The present study aimed to characterize the chemical toxicity of U in Atlantic salmon (Salmo salar) using depleted uranium (DU) as a test model. The fish were exposed to three environmentally relevant concentrations of DU (0.25, 0.5 and 1.0 mg U/L) for 48 h. Hepatic transcriptional responses were studied using microarrays in combination with quantitative real-time reverse transcription polymerase chain reaction (qPCR). Plasma variables and chromosomal damages were also studied to link transcriptional responses to potential physiological changes at higher levels. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 22% |
Student > Ph. D. Student | 6 | 22% |
Student > Master | 4 | 15% |
Professor > Associate Professor | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 1 | 4% |
Unknown | 6 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 19% |
Environmental Science | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Chemistry | 2 | 7% |
Immunology and Microbiology | 1 | 4% |
Other | 4 | 15% |
Unknown | 9 | 33% |