Title |
DNA copy number evolution in Drosophila cell lines
|
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Published in |
Genome Biology, August 2014
|
DOI | 10.1186/gb-2014-15-8-r70 |
Pubmed ID | |
Authors |
Hangnoh Lee, C Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Dayu Zhang, Lijun Zhan, Alissa Resch, Justen Andrews, Susan E Celniker, Peter Cherbas, Teresa M Przytycka, Maurizio Gatti, Brian Oliver, Brenton Graveley, David MacAlpine |
Abstract |
Structural rearrangements of the genome resulting in genic imbalance due to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines and tumors, where they may be an advantage to cells. In order to explore the biological consequences of copy number changes in the Drosophila genome, we resequenced the genomes of 19 tissue-culture cell lines and generated RNA-Seq profiles. |
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United Kingdom | 2 | 14% |
Benin | 1 | 7% |
Sweden | 1 | 7% |
France | 1 | 7% |
Japan | 1 | 7% |
Unknown | 4 | 29% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 50% |
Scientists | 6 | 43% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
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United States | 3 | 3% |
France | 2 | 2% |
Austria | 1 | 1% |
Netherlands | 1 | 1% |
Russia | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 89 | 91% |
Demographic breakdown
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---|---|---|
Researcher | 26 | 27% |
Student > Ph. D. Student | 22 | 22% |
Student > Bachelor | 15 | 15% |
Student > Master | 15 | 15% |
Other | 3 | 3% |
Other | 4 | 4% |
Unknown | 13 | 13% |
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Biochemistry, Genetics and Molecular Biology | 36 | 37% |
Agricultural and Biological Sciences | 34 | 35% |
Computer Science | 6 | 6% |
Neuroscience | 2 | 2% |
Chemistry | 2 | 2% |
Other | 4 | 4% |
Unknown | 14 | 14% |