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Effects of dexmedetomidine on TNF-α and interleukin-2 in serum of rats with severe craniocerebral injury

Overview of attention for article published in BMC Anesthesiology, September 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

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5 tweeters

Citations

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13 Dimensions

Readers on

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15 Mendeley
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Title
Effects of dexmedetomidine on TNF-α and interleukin-2 in serum of rats with severe craniocerebral injury
Published in
BMC Anesthesiology, September 2017
DOI 10.1186/s12871-017-0410-7
Pubmed ID
Authors

Wan-Wei Jiang, Qing-Hui Wang, Ya-Jing Liao, Pai Peng, Min Xu, Li-Xin Yin

Abstract

Dexmedetomidine is a highly selective adrenergic receptor agonist, which has a dose-dependent sedative hypnotic effect. Furthermore, it also has pharmacological properties, and the ability to inhibit sympathetic activity and improve cardiovascular stability during an operation. However, its protective effect on patients with severe craniocerebral injury in the perioperative period remains unclear. Eighty adult male SD rats were used and divided into two groups (n = 40, each group): dexmedetomidine injury group (experimental group), and sodium chloride injury group (control group). Models of severe craniocerebral injury were established in these two groups using the modified Feeney's free-fall method. As soon as the establishment of models was succeed, rat in the experimental group received 1 μg of dexmedetomidine (0.1 ml), while each rat in the control group was given 0.1 ml of 0.9% sodium chloride. Blood was sampled from an incision at the femoral vein to detect TNF-α and IL-2 levels at 1, 12, 24,36,48 and 72 h after establishing the model in the two groups. After severe craniocerebral injury, TNF-α levels of rats were lower in every stage and at different degrees in the experimental group than in the control group (P < 0.05), while IL-2 levels were lower in the experimental group to different extents (P < 0.05). Dexmedetomidine protects the brain of rats with severe craniocerebral injury by reducing the release of inflammatory mediators.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 27%
Student > Doctoral Student 3 20%
Professor > Associate Professor 2 13%
Student > Master 2 13%
Student > Ph. D. Student 1 7%
Other 2 13%
Unknown 1 7%
Readers by discipline Count As %
Neuroscience 4 27%
Medicine and Dentistry 4 27%
Agricultural and Biological Sciences 2 13%
Nursing and Health Professions 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 0 0%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2017.
All research outputs
#8,216,364
of 15,840,902 outputs
Outputs from BMC Anesthesiology
#210
of 1,010 outputs
Outputs of similar age
#109,968
of 277,726 outputs
Outputs of similar age from BMC Anesthesiology
#1
of 1 outputs
Altmetric has tracked 15,840,902 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,010 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,726 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them