Title |
Common variants explain a large fraction of the variability in the liability to psoriasis in a Han Chinese population
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Published in |
BMC Genomics, January 2014
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DOI | 10.1186/1471-2164-15-87 |
Pubmed ID | |
Authors |
Xianyong Yin, Nathan E Wineinger, Hui Cheng, Yong Cui, Fusheng Zhou, Xianbo Zuo, Xiaodong Zheng, Sen Yang, Nicholas J Schork, Xuejun Zhang |
Abstract |
Psoriasis is a common inflammatory skin disease with a known genetic component. Our previously published psoriasis genome-wide association study identified dozens of novel susceptibility loci in Han Chinese. However, these markers explained only a small fraction of the estimated heritable component of psoriasis. To better understand the unknown yet likely polygenic architecture in psoriasis, we applied a linear mixed model to quantify the variation in the liability to psoriasis explained by common genetic markers (minor allele frequency > 0.01) in a Han Chinese population. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 26% |
Professor > Associate Professor | 3 | 13% |
Student > Ph. D. Student | 2 | 9% |
Unspecified | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 2 | 9% |
Unknown | 8 | 35% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 22% |
Medicine and Dentistry | 3 | 13% |
Nursing and Health Professions | 2 | 9% |
Mathematics | 1 | 4% |
Unspecified | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 43% |