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The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome

Overview of attention for article published in Malaria Journal, September 2017
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Title
The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome
Published in
Malaria Journal, September 2017
DOI 10.1186/s12936-017-2006-6
Pubmed ID
Authors

Kinanga Kiaco, António Sebastião Rodrigues, Virgílio do Rosário, José Pedro Gil, Dinora Lopes

Abstract

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 23%
Researcher 5 16%
Lecturer > Senior Lecturer 2 6%
Student > Postgraduate 2 6%
Student > Ph. D. Student 2 6%
Other 5 16%
Unknown 8 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 29%
Agricultural and Biological Sciences 5 16%
Medicine and Dentistry 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2017.
All research outputs
#19,162,324
of 24,400,706 outputs
Outputs from Malaria Journal
#5,112
of 5,827 outputs
Outputs of similar age
#235,128
of 322,393 outputs
Outputs of similar age from Malaria Journal
#124
of 127 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,827 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,393 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.