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MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer

Overview of attention for article published in BMC Cancer, September 2017
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Title
MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
Published in
BMC Cancer, September 2017
DOI 10.1186/s12885-017-3642-5
Pubmed ID
Authors

Sunyoung Park, Kiyoon Eom, Jungho Kim, Hyeeun Bang, Hye-young Wang, Sungwoo Ahn, Geehyuk Kim, Hyoungsoon Jang, Sunghyun Kim, Dongsup Lee, Kwang Hwa Park, Hyeyoung Lee

Abstract

Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulating several cellular processes. However, HPV infection is not sufficient for cervical carcinoma development. Therefore, other genetic and epigenetic factors may be involved in this complex disease, and the identification of which may lead to better diagnosis and treatment. Our aim was to analyze the expression of microRNAs in cervical cancer cases positive or negative for HPV E6/E7 mRNA, and to assess their diagnostic usefulness and relevance. The expression of three different microRNAs (miR-9, miR-21, and miR-155) in 52 formalin-fixed paraffin-embedded (FFPE) primary cervical cancer tissue samples and 50 FFPE normal cervical tissue samples were evaluated. MiR-9, miR-21, and miR-155 were significantly overexpressed in cervical cancer tissues compared to normal tissues (P < 0.001). MiR-21 and miR-155 expression combined with the HPV E6/E7 mRNA assay in HPV E6/E7 negative cervical cancer showed increased AUC of 0.7267 and 0.7000, respectively (P = 0.01, P = 0.04), demonstrating their potential as diagnostic tools. Moreover, miR-21 and miR-155 were predictors showing a 7 fold and 10.3 fold higher risk for HPV E6/E7 negative patients with cervical cancer (P = 0.024 and P = 0.017, respectively) while miR-155 was a predictor showing a 27.9 fold higher risk for HPV E6/E7 positive patients with cervical cancer (P < 0.0001). There is a strong demand for additional, alternative molecular biomarkers for diagnosis and management of precancer patients. MiR-21 and miR-155 may be helpful in the prediction of both HPV positive and HPV negative cases of cervical cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 16%
Student > Master 10 14%
Student > Ph. D. Student 8 11%
Researcher 7 9%
Other 4 5%
Other 14 19%
Unknown 19 26%
Readers by discipline Count As %
Medicine and Dentistry 18 24%
Biochemistry, Genetics and Molecular Biology 18 24%
Immunology and Microbiology 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Agricultural and Biological Sciences 3 4%
Other 6 8%
Unknown 21 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2017.
All research outputs
#14,623,847
of 16,578,610 outputs
Outputs from BMC Cancer
#4,830
of 6,083 outputs
Outputs of similar age
#239,375
of 280,209 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
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