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The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases

Overview of attention for article published in BMC Veterinary Research, August 2014
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Title
The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases
Published in
BMC Veterinary Research, August 2014
DOI 10.1186/s12917-014-0202-y
Pubmed ID
Authors

Wei-Li Hsu, Hsiao-Chi Chiou, Kwong-chung Tung, Guillaume Belot, Anais Virilli, Min-Liang Wong, Fong-Yuan Lin, Ya-Jane Lee

Abstract

BackgroundNeutrophil gelatinase-associated lipocalin (NGAL) is a useful biomarker for the early prediction of renal diseases. NGAL may exist as monomer, dimer and/or NGAL/MMP-9 complex forms in humans. In this study, the existence of various forms of NGAL in urine (uNGAL) was determined and whether these forms are related to the different urinary diseases found in dogs is further discussed.ResultsEighty-one urine samples from dogs with different forms of renal disease (41), pyuria (19) and a number of non-renal related diseases (10), as well as healthy dogs (11), were collected. uNGAL concentrations and their molecular forms in dogs were measured by ELISA and Western blot analysis, respectively. The uNGAL concentrations of dogs with pyuria (median: 15.35 ng / mL) were significantly higher than those of the healthy control animals (median: 3.92 ng / mL) (p¿<¿0.01), but lower than those of dogs with renal diseases (median: 23.77 ng / mL). Each NGAL molecular form could be detected in dog urine. In particular, monomer was detected more frequently in patients with renal disease than those with non-renal diseases; while the dimer form appeared in a significantly higher percentage of cases with pyuria compared to those without pyuria. The NGAL/MMP-9 complex was found to exist not only in the patients with cystitis, but also in the cases with renal injury.ConclusionDifferent molecular forms of uNGAL can indicate different origins of the urinary abnormalities. Determining the molecular forms of uNGAL present in diseased dogs may provide clinical workers with a tool that will help the early and more precise detection of different urinary diseases.

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 19%
Student > Ph. D. Student 4 15%
Student > Bachelor 3 12%
Researcher 3 12%
Lecturer > Senior Lecturer 2 8%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 10 38%
Medicine and Dentistry 3 12%
Agricultural and Biological Sciences 2 8%
Biochemistry, Genetics and Molecular Biology 1 4%
Immunology and Microbiology 1 4%
Other 3 12%
Unknown 6 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2014.
All research outputs
#3,569,863
of 4,507,652 outputs
Outputs from BMC Veterinary Research
#621
of 795 outputs
Outputs of similar age
#86,200
of 115,871 outputs
Outputs of similar age from BMC Veterinary Research
#47
of 55 outputs
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