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A double blind randomized controlled trial in neonates to determine the effect of vitamin A supplementation on immune responses: The Gambia protocol

Overview of attention for article published in BMC Pediatrics, April 2014
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3 X users

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116 Mendeley
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Title
A double blind randomized controlled trial in neonates to determine the effect of vitamin A supplementation on immune responses: The Gambia protocol
Published in
BMC Pediatrics, April 2014
DOI 10.1186/1471-2431-14-92
Pubmed ID
Authors

Suzanna LR McDonald, Mathilde Savy, Anthony JC Fulford, Lindsay Kendall, Katie L Flanagan, Andrew M Prentice

Abstract

Vitamin A supplementation significantly reduces all-cause mortality when given between 6-59 months of age, but has a null or detrimental effect when given between 1-5 months. Studies of neonatal vitamin A supplementation conducted across Africa and South Asia have produced conflicting findings. These age-pattern variations might result from immunological interactions between vitamin A supplementation and vaccines. Knowledge on the potential immunological sequelae of human neonatal vitamin A supplementation is so scarce that the foremost aim of this study is to seek indicative data on aspects of immunity likely to be affected by neonatal vitamin A supplementation. The objective of this trial is to test whether human neonatal vitamin A supplementation modulates immune function including improved thymic maturation in infancy and improved systemic immune responses to routine immunization.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Peru 1 <1%
Unknown 114 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 17%
Researcher 18 16%
Student > Bachelor 17 15%
Student > Ph. D. Student 15 13%
Student > Postgraduate 5 4%
Other 10 9%
Unknown 31 27%
Readers by discipline Count As %
Medicine and Dentistry 32 28%
Nursing and Health Professions 14 12%
Agricultural and Biological Sciences 9 8%
Social Sciences 7 6%
Immunology and Microbiology 6 5%
Other 12 10%
Unknown 36 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2014.
All research outputs
#14,199,380
of 22,761,738 outputs
Outputs from BMC Pediatrics
#1,811
of 2,992 outputs
Outputs of similar age
#119,421
of 226,153 outputs
Outputs of similar age from BMC Pediatrics
#29
of 59 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,992 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,153 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.