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Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae

Overview of attention for article published in BMC Genomics, September 2014
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Title
Characteristics of replication-independent endogenous double-strand breaks in Saccharomyces cerevisiae
Published in
BMC Genomics, September 2014
DOI 10.1186/1471-2164-15-750
Pubmed ID
Authors

Monnat Pongpanich, Maturada Patchsung, Jirapan Thongsroy, Apiwat Mutirangura

Abstract

Replication-independent endogenous double-strand breaks (RIND-EDSBs) occur in both humans and yeast in the absence of inductive agents and DNA replication. In human cells, RIND-EDSBs are hypermethylated, preferentially retained in the heterochromatin and unbound by γ-H2AX. In single gene deletion yeast strains, the RIND-EDSB levels are altered; the number of RIND-EDSBs is higher in strains with deletions of histone deacetylase, endonucleases, topoisomerase, or DNA repair regulators, but lower in strains with deletions of the high-mobility group box proteins or Sir2. In summary, RIND-EDSBs are different from pathologic DSBs in terms of their causes and consequences. In this study, we identified the nucleotide sequences surrounding RIND-EDSBs and investigated the features of these sequences as well as their break locations.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 43%
Student > Bachelor 2 14%
Student > Ph. D. Student 2 14%
Lecturer > Senior Lecturer 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 36%
Engineering 2 14%
Medicine and Dentistry 2 14%
Computer Science 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 2 14%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 September 2014.
All research outputs
#17,725,418
of 22,761,738 outputs
Outputs from BMC Genomics
#7,550
of 10,638 outputs
Outputs of similar age
#159,577
of 237,234 outputs
Outputs of similar age from BMC Genomics
#115
of 184 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,638 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 184 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.