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Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma

Overview of attention for article published in BMC Cancer, September 2014
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Title
Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma
Published in
BMC Cancer, September 2014
DOI 10.1186/1471-2407-14-648
Pubmed ID
Authors

Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin, Johan Wennerberg

Abstract

Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Cuba 1 4%
United States 1 4%
Unknown 23 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 24%
Student > Bachelor 4 16%
Other 3 12%
Unspecified 2 8%
Student > Doctoral Student 2 8%
Other 4 16%
Unknown 4 16%
Readers by discipline Count As %
Medicine and Dentistry 11 44%
Biochemistry, Genetics and Molecular Biology 4 16%
Agricultural and Biological Sciences 2 8%
Unspecified 2 8%
Unknown 6 24%