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Meta-analysis of randomized phase II trials to inform subsequent phase III decisions

Overview of attention for article published in Trials, September 2014
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Title
Meta-analysis of randomized phase II trials to inform subsequent phase III decisions
Published in
Trials, September 2014
DOI 10.1186/1745-6215-15-346
Pubmed ID
Authors

Danielle L Burke, Lucinda J Billingham, Alan J Girling, Richard D Riley

Abstract

If multiple Phase II randomized trials exist then meta-analysis is favorable to increase statistical power and summarize the existing evidence about an intervention's effect in order to help inform Phase III decisions. We consider some statistical issues for meta-analysis of Phase II trials for this purpose, as motivated by a real example involving nine Phase II trials of bolus thrombolytic therapy in acute myocardial infarction with binary outcomes.

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Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
China 1 3%
Australia 1 3%
Unknown 30 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Researcher 6 18%
Other 2 6%
Lecturer 2 6%
Student > Bachelor 2 6%
Other 7 21%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 11 33%
Psychology 4 12%
Mathematics 2 6%
Nursing and Health Professions 1 3%
Immunology and Microbiology 1 3%
Other 8 24%
Unknown 6 18%