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Meta-analysis of randomized phase II trials to inform subsequent phase III decisions

Overview of attention for article published in Trials, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

1 blog
13 tweeters


10 Dimensions

Readers on

28 Mendeley
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Meta-analysis of randomized phase II trials to inform subsequent phase III decisions
Published in
Trials, September 2014
DOI 10.1186/1745-6215-15-346
Pubmed ID

Danielle L Burke, Lucinda J Billingham, Alan J Girling, Richard D Riley


If multiple Phase II randomized trials exist then meta-analysis is favorable to increase statistical power and summarize the existing evidence about an intervention's effect in order to help inform Phase III decisions. We consider some statistical issues for meta-analysis of Phase II trials for this purpose, as motivated by a real example involving nine Phase II trials of bolus thrombolytic therapy in acute myocardial infarction with binary outcomes.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 4%
China 1 4%
Australia 1 4%
Unknown 25 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 29%
Researcher 6 21%
Lecturer 2 7%
Other 2 7%
Student > Master 2 7%
Other 5 18%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 11 39%
Psychology 4 14%
Mathematics 2 7%
Business, Management and Accounting 1 4%
Immunology and Microbiology 1 4%
Other 5 18%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2020.
All research outputs
of 21,326,395 outputs
Outputs from Trials
of 5,442 outputs
Outputs of similar age
of 215,361 outputs
Outputs of similar age from Trials
of 1 outputs
Altmetric has tracked 21,326,395 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,442 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,361 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them