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Protein recycling pathways in neurodegenerative diseases

Overview of attention for article published in Alzheimer's Research & Therapy, March 2014
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Title
Protein recycling pathways in neurodegenerative diseases
Published in
Alzheimer's Research & Therapy, March 2014
DOI 10.1186/alzrt243
Pubmed ID
Authors

Faisal Fecto, Y Taylan Esengul, Teepu Siddique

Abstract

Many progressive neurodegenerative diseases, including Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, and frontotemporal lobe dementia, are associated with the formation of insoluble intracellular proteinaceous inclusions. It is therefore imperative to understand the factors that regulate normal, as well as abnormal, protein recycling in neurons. Dysfunction of the ubiquitin-proteasome or autophagy pathways might contribute to the pathology of various neurodegenerative diseases. Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Germany 1 2%
Switzerland 1 2%
Australia 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 24%
Researcher 10 17%
Student > Bachelor 7 12%
Student > Master 7 12%
Student > Doctoral Student 6 10%
Other 6 10%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 25%
Biochemistry, Genetics and Molecular Biology 14 24%
Neuroscience 6 10%
Medicine and Dentistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 8 14%
Unknown 9 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2014.
All research outputs
#15,169,949
of 25,374,647 outputs
Outputs from Alzheimer's Research & Therapy
#1,306
of 1,465 outputs
Outputs of similar age
#120,587
of 235,895 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#10
of 12 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,465 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,895 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.