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Repair rather than segregation of damage is the optimal unicellular aging strategy

Overview of attention for article published in BMC Biology, August 2014
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Title
Repair rather than segregation of damage is the optimal unicellular aging strategy
Published in
BMC Biology, August 2014
DOI 10.1186/s12915-014-0052-x
Pubmed ID
Authors

Robert J Clegg, Rosemary J Dyson, Jan-Ulrich Kreft

Abstract

How aging, being unfavourable for the individual, can evolve is one of the fundamental problems of biology. Evidence for aging in unicellular organisms is far from conclusive. Some studies found aging even in symmetrically dividing unicellular species; others did not find aging in the same, or in different, unicellular species, or only under stress. Mathematical models suggested that segregation of non-genetic damage, as an aging strategy, would increase fitness. However, these models failed to consider repair as an alternative strategy or did not properly account for the benefits of repair. We used a new and improved individual-based model to examine rigorously the effect of a range of aging strategies on fitness in various environments.

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The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 25%
Researcher 15 23%
Student > Bachelor 6 9%
Student > Master 6 9%
Student > Doctoral Student 4 6%
Other 13 20%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 35%
Biochemistry, Genetics and Molecular Biology 16 25%
Physics and Astronomy 4 6%
Mathematics 3 5%
Nursing and Health Professions 2 3%
Other 7 11%
Unknown 10 15%