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Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria

Overview of attention for article published in Malaria Journal, September 2014
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Title
Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria
Published in
Malaria Journal, September 2014
DOI 10.1186/1475-2875-13-354
Pubmed ID
Authors

Alyssa Baccarella, Brian W Huang, Mary F Fontana, Charles C Kim

Abstract

Malaria, caused by Plasmodium sp. parasites, is a leading cause of global morbidity and mortality. Cerebral malaria, characterized by neurological symptoms, is a life-threatening complication of malaria affecting over 500,000 young children in Africa every year. Because of the prevalence and severity of cerebral malaria, a better understanding of the underlying molecular mechanisms of its pathology is desirable and could inform future development of therapeutics. This study sought to clarify the role of Toll-like receptors (TLRs) in promoting immunopathology associated with cerebral malaria, with a particular focus on the understudied TLR7.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Brazil 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 5 19%
Student > Ph. D. Student 5 19%
Student > Doctoral Student 3 11%
Student > Bachelor 3 11%
Other 3 11%
Unknown 3 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 41%
Medicine and Dentistry 5 19%
Immunology and Microbiology 2 7%
Biochemistry, Genetics and Molecular Biology 2 7%
Social Sciences 2 7%
Other 2 7%
Unknown 3 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2015.
All research outputs
#17,726,563
of 22,763,032 outputs
Outputs from Malaria Journal
#4,841
of 5,554 outputs
Outputs of similar age
#160,333
of 238,416 outputs
Outputs of similar age from Malaria Journal
#83
of 113 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,416 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.