Title |
Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria
|
---|---|
Published in |
Malaria Journal, September 2014
|
DOI | 10.1186/1475-2875-13-354 |
Pubmed ID | |
Authors |
Alyssa Baccarella, Brian W Huang, Mary F Fontana, Charles C Kim |
Abstract |
Malaria, caused by Plasmodium sp. parasites, is a leading cause of global morbidity and mortality. Cerebral malaria, characterized by neurological symptoms, is a life-threatening complication of malaria affecting over 500,000 young children in Africa every year. Because of the prevalence and severity of cerebral malaria, a better understanding of the underlying molecular mechanisms of its pathology is desirable and could inform future development of therapeutics. This study sought to clarify the role of Toll-like receptors (TLRs) in promoting immunopathology associated with cerebral malaria, with a particular focus on the understudied TLR7. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Brazil | 1 | 4% |
Unknown | 25 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 19% |
Researcher | 5 | 19% |
Student > Ph. D. Student | 5 | 19% |
Student > Doctoral Student | 3 | 11% |
Student > Bachelor | 3 | 11% |
Other | 3 | 11% |
Unknown | 3 | 11% |
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Medicine and Dentistry | 5 | 19% |
Immunology and Microbiology | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Social Sciences | 2 | 7% |
Other | 2 | 7% |
Unknown | 3 | 11% |