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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Procalcitonin guidance for reduction of antibiotic use in patients hospitalized with severe acute exacerbations of asthma: a randomized controlled study with 12-month follow-up
|
|---|---|
| Published in |
Critical Care, September 2014
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| DOI | 10.1186/s13054-014-0471-7 |
| Pubmed ID | |
| Authors |
Wei Long, Li-juan Li, Gao-zhong Huang, Xue-min Zhang, Yi-cui Zhang, Jian-guo Tang, Yu Zhang, Gang Lu |
| Abstract |
IntroductionPatients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment. We aimed to determine whether serum procalcitonin (PCT) levels can effectively and safely reduce antibiotic exposure in patients experiencing exacerbations of asthma.MethodsIn this randomized controlled trial, a total of 216 patients requiring hospitalization for severe acute exacerbations of asthma were screened for eligibility to participate in this study and 169 completed 12-month follow-up visit. Patients were randomized to either PCT-guided (PCT group) or standard antimicrobial therapy (control group). In the control group, patients received antibiotics according to the attending physician; in the PCT group, patients received antibiotics according to an algorithm based on serum PCT levels. The primary endpoint was antibiotic exposure; secondary endpoints were clinical recovery, length of hospital stay, clinical and laboratory parameters, spirometry, numbers of asthma exacerbations, emergency room visits, hospitalizations and need for corticosteroid use due to asthma.ResultsPCT guidance reduced antibiotic prescription (48.9% versus 87.8%, respectively; P <0.001) and antibiotic exposure (relative risk, 0.56; 95% confidence interval, 0.44 to 0.70; P <0.001) compared to standard therapy. There were no significant differences in clinical recovery, length of hospital stay, clinical, laboratory, spirometry outcomes in both groups. Numbers of asthma exacerbations, emergency room visits, hospitalizations and need for corticosteroid use due to asthma were similar during 12-month follow-up period.ConclusionA PCT-guided strategy allows antibiotic exposure to be reduced in patients with severe acute exacerbation of asthma without apparent harm.Trial registrationChinese Clinical Trial Register ChiCTR-TRC-12002534. Registered 26 September 2012. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 40% |
| Mexico | 1 | 20% |
| France | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Switzerland | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 75 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 12 | 15% |
| Student > Master | 10 | 13% |
| Researcher | 8 | 10% |
| Student > Postgraduate | 6 | 8% |
| Student > Ph. D. Student | 5 | 6% |
| Other | 17 | 22% |
| Unknown | 20 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 44% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Nursing and Health Professions | 2 | 3% |
| Computer Science | 2 | 3% |
| Other | 8 | 10% |
| Unknown | 21 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2018.
All research outputs
#2,329,832
of 25,373,627 outputs
Outputs from Critical Care
#2,051
of 6,554 outputs
Outputs of similar age
#24,036
of 250,098 outputs
Outputs of similar age from Critical Care
#18
of 112 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,554 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.8. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.