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In vitro and in vivo antischistosomal activity of ferroquine derivatives

Overview of attention for article published in Parasites & Vectors, September 2014
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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3 X users
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1 Facebook page

Citations

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24 Dimensions

Readers on

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43 Mendeley
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Title
In vitro and in vivo antischistosomal activity of ferroquine derivatives
Published in
Parasites & Vectors, September 2014
DOI 10.1186/1756-3305-7-424
Pubmed ID
Authors

Jennifer Keiser, Mireille Vargas, Riccardo Rubbiani, Gilles Gasser, Christophe Biot

Abstract

Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activity of ferroquine against Schistosoma mansoni adult worms and newly transformed schistosomula (NTS) in vitro and in vivo. Hydroxyl-ferroquine and ruthenoquine were included to study the potential role of reactive oxygen species in the antischistosomal activity. Mefloquine, well described for its antischistosomal properties, served as comparator.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Ph. D. Student 7 16%
Student > Bachelor 5 12%
Student > Master 4 9%
Student > Postgraduate 2 5%
Other 3 7%
Unknown 12 28%
Readers by discipline Count As %
Chemistry 11 26%
Medicine and Dentistry 7 16%
Agricultural and Biological Sciences 6 14%
Biochemistry, Genetics and Molecular Biology 2 5%
Veterinary Science and Veterinary Medicine 2 5%
Other 4 9%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2015.
All research outputs
#15,169,543
of 25,374,647 outputs
Outputs from Parasites & Vectors
#2,765
of 5,988 outputs
Outputs of similar age
#124,119
of 249,408 outputs
Outputs of similar age from Parasites & Vectors
#37
of 91 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,988 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,408 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.