Title |
In vitro and in vivo antischistosomal activity of ferroquine derivatives
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Published in |
Parasites & Vectors, September 2014
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DOI | 10.1186/1756-3305-7-424 |
Pubmed ID | |
Authors |
Jennifer Keiser, Mireille Vargas, Riccardo Rubbiani, Gilles Gasser, Christophe Biot |
Abstract |
Schistosomiasis is a neglected tropical disease and drug-repurposing is a useful strategy to fill its exhausted drug development pipeline. The ferrocenyl analogue of chloroquine, ferroquine, is an antimalarial in late-stage drug development. The aim of the present work was to study the antischistosomal activity of ferroquine against Schistosoma mansoni adult worms and newly transformed schistosomula (NTS) in vitro and in vivo. Hydroxyl-ferroquine and ruthenoquine were included to study the potential role of reactive oxygen species in the antischistosomal activity. Mefloquine, well described for its antischistosomal properties, served as comparator. |
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