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Attention Score in Context
| Title |
The prognostic value of microRNA-126 and microvessel density in patients with stage II colon cancer: results from a population cohort
|
|---|---|
| Published in |
Journal of Translational Medicine, September 2014
|
| DOI | 10.1186/s12967-014-0254-6 |
| Pubmed ID | |
| Authors |
Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, Søren Morgenthaler, Thorarinn Blondal, Jan Lindebjerg, Anders Jakobsen, Flemming Brandt Sørensen |
| Abstract |
BackgroundAngiogenesis plays a pivotal role in malignant tumour growth and the metastatic process. We analysed the prognostic value of two angiogenesis parameters, microRNA-126 (miRNA-126) and microvessel density (MVD), in a population based cohort of patients operated for stage II colon cancer.MethodsA total of 560 patients were included. Analyses were performed on formalin fixed paraffin embedded tissue from the primary tumours. The analysis of miRNA-126 expression was performed by qPCR. Microvessels were visualised by CD105 and quantified in hot spots using a light microscope. The analyses were correlated with recurrence-free cancer specific survival (RF-CSS) and overall survival (OS).ResultsLow miRNA-126 expression was significantly correlated to T4, high malignancy grade, tumour perforation, fixation, and the presence of microsatellite instability. A prognostic impact on OS was detected in the simple analysis favouring patients with high miRNA-126 expression p¿=¿0.03, and borderline significance as to RF-CSS, p¿=¿0.08. The impact on OS demonstrated borderline significance in a following multiple Cox regression analysis, hazard ratio 0.76 (95% confidence interval, 0.58-1.00), p¿=¿0.051. The MVD estimate was not associated with either RF-CSS, p¿=¿0.49, or OS, p¿=¿0.94.ConclusionThe current population based study of patients operated for stage II colon cancer demonstrated correlations between several prognostic unfavourable characteristics and miRNA-126 and argues for a possible prognostic impact on overall survival. An influence on survival by the MVD estimate was not detected. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 22% |
| Student > Ph. D. Student | 4 | 17% |
| Professor | 3 | 13% |
| Other | 2 | 9% |
| Student > Doctoral Student | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 35% |
| Medicine and Dentistry | 5 | 22% |
| Agricultural and Biological Sciences | 5 | 22% |
| Nursing and Health Professions | 1 | 4% |
| Unknown | 4 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2014.
All research outputs
#20,236,620
of 22,763,032 outputs
Outputs from Journal of Translational Medicine
#3,305
of 3,980 outputs
Outputs of similar age
#200,246
of 238,994 outputs
Outputs of similar age from Journal of Translational Medicine
#62
of 81 outputs
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.