Title |
Calcineurin and glial signaling: neuroinflammation and beyond
|
---|---|
Published in |
Journal of Neuroinflammation, September 2014
|
DOI | 10.1186/s12974-014-0158-7 |
Pubmed ID | |
Authors |
Jennifer L Furman, Christopher M Norris |
Abstract |
Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation. Several studies suggest that harmful immune/inflammatory responses may be the most impactful consequence of aberrant CN activity in glial cells. However, newly identified roles for CN in glutamate uptake, gap junction regulation, Ca2+ dyshomeostasis, and amyloid production suggest that CN¿s influence in glia may extend well beyond neuroinflammation. The following review will discuss the various actions of CN in glial cells, with particular emphasis on astrocytes, and consider the implications for neurologic dysfunction arising with aging, injury, and/or neurodegenerative disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 1% |
Unknown | 84 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 20% |
Researcher | 10 | 12% |
Student > Master | 10 | 12% |
Student > Bachelor | 8 | 9% |
Professor | 4 | 5% |
Other | 12 | 14% |
Unknown | 24 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 20 | 24% |
Agricultural and Biological Sciences | 18 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Medicine and Dentistry | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 5 | 6% |
Unknown | 29 | 34% |