Title |
AmpC and extended spectrum beta-lactamases production among urinary isolates from a tertiary care hospital in Lalitpur, Nepal
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Published in |
BMC Research Notes, September 2017
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DOI | 10.1186/s13104-017-2784-5 |
Pubmed ID | |
Authors |
Suman Rai, Narayan Dutt Pant, Raju Bhandari, Anil Giri, Roshan Parajuli, Manoj Aryal, Jyoti Amatya, Vijay Kumar Sharma |
Abstract |
Production of AmpC and extended spectrum beta-lactamases among urinary isolates has created a serious problem to the successful management of the urinary tract infection. The main purpose of this study was to determine the rates of the extended spectrum beta-lactamase (ESBL) production and AmpC beta-lactamase (ABL) production among urinary isolates. Among total 564 urinary isolates, 514 (91.1%) were gram negative bacilli and 50 (8.9%) were gram positive cocci. E. coli (76.1%) was the most common bacteria isolated. Staphylococcus aureus (6.7%) was the predominant gram positive bacteria isolated. 35 (6.8%) of the 514 gram negative bacilli were ESBL producers. Similarly, 14 (2.7%) of the gram negative bacilli were ABL producers. Only one isolate was ESBL and ABL co-producer. Highest rate of susceptibility of gram negative bacteria was seen toward amikacin (97.3%) followed by imipenem (94.4%). Similarly, highest rate of susceptibility among gram positive cocci was seen toward vancomycin (100%) followed by amikacin (93.5%). Low rates of AmpC and extended spectrum beta-lactamases production in comparison to other previous studies were reported. On the basis of the antimicrobial susceptibility patterns of the bacteria we reported in our study, amikacin, imipenem and nitrofurantoin can be used for the preliminary treatment of urinary tract infections caused by gram negative bacteria and vancomycin and amikacin for treatment of urinary tract infections caused by gram positive bacteria. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 20% |
Researcher | 6 | 13% |
Student > Bachelor | 3 | 7% |
Student > Ph. D. Student | 3 | 7% |
Other | 2 | 4% |
Other | 5 | 11% |
Unknown | 18 | 39% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 12 | 26% |
Medicine and Dentistry | 7 | 15% |
Veterinary Science and Veterinary Medicine | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 11% |
Unknown | 15 | 33% |