Title |
The impact of structural integrity and route of administration on the antibody specificity against three cow's milk allergens ‐ a study in Brown Norway rats
|
---|---|
Published in |
Clinical and Translational Allergy, August 2014
|
DOI | 10.1186/2045-7022-4-25 |
Pubmed ID | |
Authors |
Jeanette Lund Madsen, Stine Kroghsbo, Charlotte Bernhard Madsen, Irina Pozdnyakova, Vibeke Barkholt, Katrine Lindholm Bøgh |
Abstract |
Characterisation of the specific antibody response, including the epitope binding pattern, is an essential task for understanding the molecular mechanisms of food allergy. Examination of antibody formation in a controlled environment requires animal models. The purpose of this study was to examine the amount and types of antibodies raised against three cow's milk allergens; β-lactoglobulin (BLG), α-lactalbumin (ALA) and β-casein upon oral or intraperitoneal (i.p.) administration. A special focus was given to the relative amount of antibodies raised against linear versus conformational epitopes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 13% |
Student > Bachelor | 5 | 13% |
Researcher | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Student > Postgraduate | 3 | 8% |
Other | 5 | 13% |
Unknown | 14 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 20% |
Immunology and Microbiology | 5 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Medicine and Dentistry | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 4 | 10% |
Unknown | 15 | 38% |