Title |
The OPTIMIST-A trial: evaluation of minimally-invasive surfactant therapy in preterm infants 25–28 weeks gestation
|
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Published in |
BMC Pediatrics, August 2014
|
DOI | 10.1186/1471-2431-14-213 |
Pubmed ID | |
Authors |
Peter A Dargaville, Camille Omar F Kamlin, Antonio G De Paoli, John B Carlin, Francesca Orsini, Roger F Soll, Peter G Davis |
Abstract |
It is now recognized that preterm infants ≤28 weeks gestation can be effectively supported from the outset with nasal continuous positive airway pressure. However, this form of respiratory therapy may fail to adequately support those infants with significant surfactant deficiency, with the result that intubation and delayed surfactant therapy are then required. Infants following this path are known to have a higher risk of adverse outcomes, including death, bronchopulmonary dysplasia and other morbidities. In an effort to circumvent this problem, techniques of minimally-invasive surfactant therapy have been developed, in which exogenous surfactant is administered to a spontaneously breathing infant who can then remain on continuous positive airway pressure. A method of surfactant delivery using a semi-rigid surfactant instillation catheter briefly passed into the trachea (the "Hobart method") has been shown to be feasible and potentially effective, and now requires evaluation in a randomised controlled trial. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 33% |
Canada | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | <1% |
Unknown | 184 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 30 | 16% |
Researcher | 26 | 14% |
Other | 21 | 11% |
Student > Master | 13 | 7% |
Student > Postgraduate | 12 | 6% |
Other | 34 | 18% |
Unknown | 49 | 26% |
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Biochemistry, Genetics and Molecular Biology | 4 | 2% |
Other | 10 | 5% |
Unknown | 56 | 30% |