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G9a co-suppresses LINE1 elements in spermatogonia

Overview of attention for article published in Epigenetics & Chromatin, September 2014
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1 Google+ user

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63 Mendeley
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Title
G9a co-suppresses LINE1 elements in spermatogonia
Published in
Epigenetics & Chromatin, September 2014
DOI 10.1186/1756-8935-7-24
Pubmed ID
Authors

Monica Di Giacomo, Stefano Comazzetto, Srihari C Sampath, Srinath C Sampath, Dónal O’Carroll

Abstract

Repression of retrotransposons is essential for genome integrity and the development of germ cells. Among retrotransposons, the establishment of CpG DNA methylation and epigenetic silencing of LINE1 (L1) elements and the intracisternal A particle (IAP) endogenous retrovirus (ERV) is dependent upon the piRNA pathway during embryonic germ cell reprogramming. Furthermore, the Piwi protein Mili, guided by piRNAs, cleaves expressed L1 transcripts to post-transcriptionally enforce L1 silencing in meiotic cells. The loss of both DNA methylation and the Mili piRNA pathway does not affect L1 silencing in the mitotic spermatogonia where histone H3 lysine 9 dimethylation (H3K9me2) is postulated to co-repress these elements.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Belgium 1 2%
Unknown 60 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 25%
Researcher 12 19%
Student > Master 7 11%
Student > Bachelor 6 10%
Other 6 10%
Other 8 13%
Unknown 8 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 40%
Agricultural and Biological Sciences 24 38%
Medicine and Dentistry 4 6%
Sports and Recreations 1 2%
Unknown 9 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2014.
All research outputs
#13,919,373
of 22,763,032 outputs
Outputs from Epigenetics & Chromatin
#391
of 566 outputs
Outputs of similar age
#119,255
of 238,986 outputs
Outputs of similar age from Epigenetics & Chromatin
#5
of 12 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.