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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

Overview of attention for article published in Malaria Journal, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
54 Mendeley

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Summary Twitter Patents Dimensions citations
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Title
Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity
Published in
Malaria Journal, September 2014
DOI 10.1186/1475-2875-13-359
Pubmed ID
25218605
Authors

Sanna R Rijpma, Jeroen JMW van den Heuvel, Maarten van der Velden, Robert W Sauerwein, Frans GM Russel, Jan B Koenderink

Abstract

Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolism, and excretion. ATP binding cassette (ABC) transport proteins are particularly involved in drug deposition, as they are located at membranes of many uptake and excretory organs and at protective barriers, where they export endogenous and xenobiotic compounds, including pharmaceuticals. In this study, a panel of well-established anti-malarial drugs which may affect drug plasma concentrations was tested for interactions with human ABC transport proteins.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 2 4%
Burkina Faso 1 2%
Unknown 51 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 24%
Student > Ph. D. Student 9 17%
Student > Bachelor 8 15%
Student > Postgraduate 4 7%
Researcher 3 6%
Other 11 20%
Unknown 6 11%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 12 22%
Medicine and Dentistry 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Agricultural and Biological Sciences 7 13%
Arts and Humanities 4 7%
Other 9 17%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2018.
All research outputs
#4,507,922
of 22,763,032 outputs
Outputs from Malaria Journal
#1,141
of 5,554 outputs
Outputs of similar age
#48,482
of 245,563 outputs
Outputs of similar age from Malaria Journal
#24
of 106 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.

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