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Attention Score in Context
| Title |
Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems
|
|---|---|
| Published in |
Journal of Biomedical Science, July 2014
|
| DOI | 10.1186/s12929-014-0069-z |
| Pubmed ID | |
| Authors |
Alireza Tahamtan, Amir Ghaemi, Ali Gorji, Hamid R Kalhor, Azadeh Sajadian, Alijan Tabarraei, Abdolvahab Moradi, Fatemeh Atyabi, Mishar Kelishadi |
| Abstract |
BackgroundCervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In this study, we have designed a therapeutic vaccine based on chitosan nanodelivery systems to deliver HPV-16 E7 DNA vaccine, considered as a tumor specific antigen for immunotherapy of HPV-associated cervical cancer. We have developed a Nano-chitosan (NCS) as a carrier system for intramuscular administration using a recombinant DNA vaccine expressing HPV-16 E7 (NCS-DNA E7 vaccine). NCS were characterized in vitro for their gene transfection ability.ResultsThe transfection of CS-pEGFP NPs was efficient in CHO cells and the expression of green fluorescent proteins was well observed. In addition, NCS-DNA E7 vaccine induced the strongest E7-specific CD8+ T cell and interferon ¿ responses in C57BL/6 mice. Mice vaccinated with NCS-DNA E7 vaccine were able to generate potent protective and therapeutic antitumor effects against challenge with E7-expressing tumor cell line, TC-1.ConclusionsThe strong therapeutic effect induced by the Chitosan-based nanodelivery suggest that nanoparticles may be an efficient carrier to improve the immunogenicity of DNA vaccination upon intramuscular administration and the platform could be further exploited as a potential cancer vaccine candidate in humans. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Lebanon | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 105 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 27% |
| Student > Ph. D. Student | 21 | 20% |
| Student > Master | 12 | 11% |
| Researcher | 6 | 6% |
| Lecturer | 4 | 4% |
| Other | 18 | 17% |
| Unknown | 17 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 31 | 29% |
| Medicine and Dentistry | 19 | 18% |
| Biochemistry, Genetics and Molecular Biology | 14 | 13% |
| Immunology and Microbiology | 8 | 7% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 9 | 8% |
| Unknown | 21 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2023.
All research outputs
#7,959,659
of 25,371,288 outputs
Outputs from Journal of Biomedical Science
#325
of 1,100 outputs
Outputs of similar age
#71,043
of 239,354 outputs
Outputs of similar age from Journal of Biomedical Science
#6
of 15 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,100 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.