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MicroRNA-21 inhibits p57Kip2 expression in prostate cancer

Overview of attention for article published in Molecular Cancer, September 2014
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Title
MicroRNA-21 inhibits p57Kip2 expression in prostate cancer
Published in
Molecular Cancer, September 2014
DOI 10.1186/1476-4598-13-212
Pubmed ID
Authors

Sweta Mishra, Chun-Lin Lin, Tim H-M Huang, Hakim Bouamar, Lu-Zhe Sun

Abstract

p57Kip2, a cyclin-dependent kinase inhibitor, is considered to be a candidate tumor suppressor gene that has been implicated in Beckwith-Wiedemann syndrome and sporadic cancers. In addition, decreased expression of p57Kip2 protein has been frequently observed in pancreatic, lung, breast, bladder, gastrointestinal tract and prostate cancers. However, p57Kip2 gene mutations are rare in these cancers suggesting that other unknown mechanisms might be at play in reducing its expression. The aim of this study was to investigate the molecular mechanism of down-regulation of p57Kip2 in prostate cancer.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 27 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Researcher 4 14%
Student > Master 3 11%
Student > Bachelor 2 7%
Student > Postgraduate 2 7%
Other 2 7%
Unknown 6 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 43%
Agricultural and Biological Sciences 5 18%
Medicine and Dentistry 2 7%
Nursing and Health Professions 1 4%
Unspecified 1 4%
Other 1 4%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2014.
All research outputs
#20,236,620
of 22,763,032 outputs
Outputs from Molecular Cancer
#1,478
of 1,719 outputs
Outputs of similar age
#203,647
of 243,384 outputs
Outputs of similar age from Molecular Cancer
#40
of 42 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,384 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.