You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
|
|---|---|
| Published in |
BMC Chemistry, May 2017
|
| DOI | 10.1186/s13065-017-0266-4 |
| Pubmed ID | |
| Authors |
Sobhi M. Gomha, Mastoura M. Edrees, Rasha A. M. Faty, Zeinab A. Muhammad, Yahia N. Mabkhot |
| Abstract |
Pyrazoles, thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. An efficient and a novel approach for the synthesis of some novel pyrazole based-azoles are described via multi-component reaction under controlled microwave heating conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, (1)H NMR and mass spectral data. All the synthesized compounds were tested for in vitro activities against two antitumor cell lines, human lung cancer and human hepatocellular carcinoma compared with the employed standard antitumor drug (cisplatin). All the newly synthesized compounds were evaluated for their anticancer activity against human lung cancer and human hepatocellular carcinoma cell lines using MTT assay. The results obtained exploring the high potency of six of the tested compounds compared with cisplatin. Graphical abstract Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Professor | 2 | 5% |
| Other | 2 | 5% |
| Researcher | 2 | 5% |
| Other | 5 | 14% |
| Unknown | 19 | 51% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 12 | 32% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Sports and Recreations | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 18 | 49% |