Title |
Tryptophan depletion in chronic fatigue syndrome, a pilot cross-over study
|
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Published in |
BMC Research Notes, September 2014
|
DOI | 10.1186/1756-0500-7-650 |
Pubmed ID | |
Authors |
Gerard KH The, Robbert J Verkes, Durk Fekkes, Gijs Bleijenberg, Jos WM van der Meer, Jan K Buitelaar |
Abstract |
Chronic fatigue syndrome (CFS) is still an enigmatic disorder. CFS can be regarded as a complex disorder with tremendous impact on lives of CFS-patients. Full recovery without treatment is rare. A somatic explanation for the fatigue is lacking. There is clinical and experimental evidence implicating enhanced serotonergic neurotransmission in CFS. Genetic studies and imaging studies support the hypothesis of upregulated serotonin system in CFS. In line with the hypothesis of an increased serotonergic state in CFS, we performed a randomised clinical trial investigated the effect of 5-HT3 receptor antagonism in CFS. No benefit was found of the 5-HT3 receptor antagonist ondansetron compared to placebo.To further investigate the involvement of serotonin in CFS we performed a placebo controlled cross over pilot study investigating the effect of Acute Tryptophan Depletion. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 30% |
Japan | 2 | 20% |
Netherlands | 1 | 10% |
United Kingdom | 1 | 10% |
Unknown | 3 | 30% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 10 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 16% |
Researcher | 9 | 15% |
Student > Master | 8 | 13% |
Student > Bachelor | 8 | 13% |
Student > Doctoral Student | 5 | 8% |
Other | 13 | 21% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 15 | 24% |
Medicine and Dentistry | 9 | 15% |
Agricultural and Biological Sciences | 6 | 10% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Nursing and Health Professions | 4 | 6% |
Other | 10 | 16% |
Unknown | 13 | 21% |