Title |
Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis
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Published in |
Journal of Translational Medicine, September 2014
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DOI | 10.1186/s12967-014-0256-4 |
Pubmed ID | |
Authors |
Rashmi Gupta, Henri-Alexandre Michaud, Xue Zeng, Maya Debbaneh, Sarah T Arron, R Brad Jones, Christopher E Ormsby, Douglas F Nixon, Wilson Liao |
Abstract |
Psoriasis is a multifactorial, chronic disease of skin affecting 2-3% of the world's population. Genetic studies of psoriasis have identified a number of susceptibility genes that are involved in anti-viral immunity. Furthermore, physiological studies have also found an increase in anti-viral proteins in psoriatic skin. These findings suggest the presence of an anti-viral state in psoriatic skin. However, the triggers for this anti-viral cascade and its consequences for host immunity are not known. Endogenous retroviruses have previously been described in many autoimmune diseases including psoriasis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Iran, Islamic Republic of | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 23% |
Student > Bachelor | 7 | 18% |
Student > Ph. D. Student | 7 | 18% |
Student > Doctoral Student | 5 | 13% |
Student > Master | 2 | 5% |
Other | 3 | 8% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 28% |
Medicine and Dentistry | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Immunology and Microbiology | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 5 | 13% |
Unknown | 5 | 13% |