Title |
In vivo assessment of arterial stiffness in the isoflurane anesthetized spontaneously hypertensive rat
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Published in |
Cardiovascular Ultrasound, September 2014
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DOI | 10.1186/1476-7120-12-37 |
Pubmed ID | |
Authors |
Eric E Morgan, Andrew B Casabianca, Samer J Khouri, Andrea L Nestor Kalinoski |
Abstract |
Rodent models are increasingly used to study the development and progression of arterial stiffness. Both the non-invasive Doppler derived Pulse Wave Velocity (PWV) and the invasively determined arterial elastance index (EaI) have been used to assess arterial stiffness in rats and mice, but the need for anesthetic agents to make these in vivo estimates may limit their utility. Thus, we sought to determine: 1) if known differences in arterial stiffness in spontaneously hypertensive rats (SHR) are detectable by PWV and EaI measurements when made under isoflurane anesthesia, and 2) if these two uniquely acquired assessments of arterial elasticity correlate. |
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