Title |
Chronic traumatic encephalopathy: clinical‐biomarker correlations and current concepts in pathogenesis
|
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Published in |
Molecular Neurodegeneration, September 2014
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DOI | 10.1186/1750-1326-9-37 |
Pubmed ID | |
Authors |
Sam Gandy, Milos D Ikonomovic, Effie Mitsis, Gregory Elder, Stephen T Ahlers, Jeffrey Barth, James R Stone, Steven T DeKosky |
Abstract |
Chronic traumatic encephalopathy (CTE) is a recently revived term used to describe a neurodegenerative process that occurs as a long term complication of repetitive mild traumatic brain injury (TBI). Corsellis provided one of the classic descriptions of CTE in boxers under the name "dementia pugilistica" (DP). Much recent attention has been drawn to the apparent association of CTE with contact sports (football, soccer, hockey) and with frequent battlefield exposure to blast waves generated by improvised explosive devices (IEDs). Recently, a promising serum biomarker has been identified by measurement of serum levels of the neuronal microtubule associated protein tau. New positron emission tomography (PET) ligands (e.g., [18 F] T807) that identify brain tauopathy have been successfully deployed for the in vitro and in vivo detection of presumptive tauopathy in the brains of subjects with clinically probable CTE. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 22% |
India | 1 | 11% |
Saudi Arabia | 1 | 11% |
Mexico | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Scientists | 2 | 22% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 219 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 44 | 19% |
Student > Master | 27 | 12% |
Student > Ph. D. Student | 26 | 11% |
Researcher | 24 | 11% |
Student > Doctoral Student | 16 | 7% |
Other | 47 | 21% |
Unknown | 43 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 53 | 23% |
Neuroscience | 32 | 14% |
Agricultural and Biological Sciences | 20 | 9% |
Psychology | 16 | 7% |
Sports and Recreations | 15 | 7% |
Other | 32 | 14% |
Unknown | 59 | 26% |