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Dynamic changes in DNA modification states during late gestation male germ line development in the rat

Overview of attention for article published in Epigenetics & Chromatin, August 2014
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Title
Dynamic changes in DNA modification states during late gestation male germ line development in the rat
Published in
Epigenetics & Chromatin, August 2014
DOI 10.1186/1756-8935-7-19
Pubmed ID
Authors

Catherine M Rose, Sander van den Driesche, Richard M Sharpe, Richard R Meehan, Amanda J Drake

Abstract

Epigenetic reprogramming of fetal germ cells involves the genome-wide erasure and subsequent re-establishment of DNA methylation. Mouse studies indicate that DNA demethylation may be initiated at embryonic day (e) 8 and completed between e11.5 and e12.5. In the male germline, DNA remethylation begins around e15 and continues for the remainder of gestation whilst this process occurs postnatally in female germ cells. Although 5-methylcytosine (5mC) dynamics have been extensively characterised, a role for the more recently described DNA modifications (5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC)) remains unclear. Moreover, the extent to which the developmental dynamics of 5mC reprogramming is conserved across species remains largely undetermined. Here, we sought to describe this process during late gestation in the male rat.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 32%
Student > Doctoral Student 3 12%
Student > Bachelor 3 12%
Researcher 3 12%
Student > Master 2 8%
Other 2 8%
Unknown 4 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 32%
Agricultural and Biological Sciences 5 20%
Environmental Science 2 8%
Medicine and Dentistry 2 8%
Neuroscience 1 4%
Other 1 4%
Unknown 6 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2014.
All research outputs
#20,236,620
of 22,763,032 outputs
Outputs from Epigenetics & Chromatin
#522
of 566 outputs
Outputs of similar age
#193,733
of 230,246 outputs
Outputs of similar age from Epigenetics & Chromatin
#8
of 13 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,246 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.