Title |
Biscarbamate cross-linked low molecular weight Polyethylenimine polycation as an efficient intra-cellular delivery cargo for cancer therapy
|
---|---|
Published in |
Journal of Nanobiotechnology, April 2014
|
DOI | 10.1186/1477-3155-12-13 |
Pubmed ID | |
Authors |
Xuemei Ge, Jia Feng, Shun Chen, Can Zhang, Yuanming Ouyang, Zhenguo Liu, Weien Yuan |
Abstract |
A challenge in gene therapy is the efficient delivery of DNA/siRNA to the diseased cells. The physicochemical characteristics of siRNA, such as high molecular weight, negative charges and hydrophilic nature-prevent passive diffusion across the plasma membrane for most cells. A therapeutically feasible carrier for intra-cellular delivery of gene materials should accomplish a series of tasks such as: condensing nucleic acid, protecting nucleic acid from leaking in vivo, facilitating endosome escape and releasing DNA/siRNA to the target site. To meet these requirements, an efficient gene vector based on polycation synthesis for siRNA delivery both in vitro and in vivo was developed. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 14% |
Professor | 2 | 14% |
Professor > Associate Professor | 2 | 14% |
Student > Ph. D. Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 2 | 14% |
Unknown | 4 | 29% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 14% |
Chemistry | 2 | 14% |
Agricultural and Biological Sciences | 2 | 14% |
Medicine and Dentistry | 2 | 14% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 29% |