Title |
The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis
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Published in |
Cell Communication and Signaling, October 2013
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DOI | 10.1186/1478-811x-11-77 |
Pubmed ID | |
Authors |
Gernot Posselt, Steffen Backert, Silja Wessler |
Abstract |
Infections with the human pathogen Helicobacter pylori (H. pylori) can lead to severe gastric diseases ranging from chronic gastritis and ulceration to neoplastic changes in the stomach. Development and progress of H. pylori-associated disorders are determined by multifarious bacterial factors. Many of them interact directly with host cells or require specific receptors, while others enter the host cytoplasm to derail cellular functions. Several adhesins (e.g. BabA, SabA, AlpA/B, or OipA) establish close contact with the gastric epithelium as an important first step in persistent colonization. Soluble H. pylori factors (e.g. urease, VacA, or HtrA) have been suggested to alter cell survival and intercellular adhesions. Via a type IV secretion system (T4SS), H. pylori also translocates the effector cytotoxin-associated gene A (CagA) and peptidoglycan directly into the host cytoplasm, where cancer- and inflammation-associated signal transduction pathways can be deregulated. Through these manifold possibilities of interaction with host cells, H. pylori interferes with the complex signal transduction networks in its host and mediates a multi-step pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 1% |
Spain | 2 | 1% |
Brazil | 1 | <1% |
Colombia | 1 | <1% |
Germany | 1 | <1% |
United States | 1 | <1% |
Unknown | 156 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 25% |
Student > Bachelor | 23 | 14% |
Student > Master | 21 | 13% |
Researcher | 16 | 10% |
Student > Doctoral Student | 11 | 7% |
Other | 20 | 12% |
Unknown | 32 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 47 | 29% |
Biochemistry, Genetics and Molecular Biology | 34 | 21% |
Immunology and Microbiology | 19 | 12% |
Medicine and Dentistry | 12 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 14 | 9% |
Unknown | 34 | 21% |