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Mendeley readers
Attention Score in Context
| Title |
Skin cytokine expression in patients with fibromyalgia syndrome is not different from controls
|
|---|---|
| Published in |
BMC Neurology, September 2014
|
| DOI | 10.1186/s12883-014-0185-0 |
| Pubmed ID | |
| Authors |
Nurcan Üçeyler, Susanne Kewenig, Waldemar Kafke, Sarah Kittel-Schneider, Claudia Sommer |
| Abstract |
ObjectivesTo investigate whether skin cytokine and delta opioid receptor (DOR) gene expression in patients with fibromyalgia syndrome (FMS) differs from controls as one potential contributor to small nerve fiber sensitization.MethodsWe investigated skin punch biopsies of 25 FMS patients, ten patients with monopolar depression but no pain, and 35 healthy controls. Biopsies were obtained from the lateral upper thigh and lower calf. Gene expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF), interleukin(IL)-6, and IL-8 and of the anti-inflammatory cytokine IL-10 was analyzed using quantitative real-time PCR and normalizing data to 18sRNA as housekeeping gene. Additionally, we assessed DOR gene expression.ResultsAll cytokines and DOR were detectable in skin samples of FMS patients, patients with depression, and healthy controls without intergroup difference. Also, gene expression was not different in skin of the upper and lower leg within and between the groups and in FMS patient subgroups.ConclusionsSkin cytokine and DOR gene expression does not differ between patients with FMS and controls. Our results do not support a role of the investigated cytokines in sensitization of peripheral nerve fibers as a potential mechanism of small fiber pathology in FMS. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Unknown | 69 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 14% |
| Student > Bachelor | 10 | 14% |
| Researcher | 9 | 13% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Doctoral Student | 6 | 8% |
| Other | 15 | 21% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 30% |
| Psychology | 12 | 17% |
| Agricultural and Biological Sciences | 7 | 10% |
| Neuroscience | 3 | 4% |
| Nursing and Health Professions | 3 | 4% |
| Other | 8 | 11% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2014.
All research outputs
#17,727,479
of 22,764,165 outputs
Outputs from BMC Neurology
#1,788
of 2,428 outputs
Outputs of similar age
#169,011
of 251,438 outputs
Outputs of similar age from BMC Neurology
#25
of 40 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,428 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,438 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.