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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A mouse line for inducible and reversible silencing of specific neurons
|
|---|---|
| Published in |
Molecular Brain, September 2014
|
| DOI | 10.1186/s13041-014-0068-8 |
| Pubmed ID | |
| Authors |
Ling Hu, Wei Lan, Hao Guo, Guo-Dong Chai, Kun Huang, Ling Zhang, Ying Huang, Xue-Feng Chen, Lei Zhang, Ning-Ning Song, Ling Chen, Bing Lang, Yun Wang, Qing-Xiu Wang, Jin-Bao Zhang, Collin McCaig, Lin Xu, Yu-Qiang Ding |
| Abstract |
BackgroundGenetic methods for inducibly and reversibly inhibiting neuronal activity of specific neurons are critical for exploring the functions of neuronal circuits. The engineered human glycine receptor, called ivermectin (IVM)-gated silencing receptor (IVMR), has been shown to possess this ability in vitro.ResultsHere we generated a mouse line, in which the IVMR coding sequence was inserted into the ROSA26 locus downstream of a loxP-flanked STOP cassette. Specific Cre-mediated IVMR expression was revealed by mis-expression of Cre in the striatum and by crossing with several Cre lines. Behavioral alteration was observed in Rosa26-IVMR mice with unilateral striatal Cre expression after systemic administration of IVM, and it could be re-initiated when IVM was applied again. A dramatic reduction in neuron firing was recorded in IVM-treated free moving Rosa26-IVMR;Emx1-Cre mice, and neuronal excitability was reduced within minutes as shown by recording in brain slice.ConclusionThis Rosa26-IVMR mouse line provides a powerful tool for exploring selective circuit functions in freely behaving mice. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 36% |
| Student > Master | 5 | 18% |
| Researcher | 5 | 18% |
| Professor | 5 | 18% |
| Other | 1 | 4% |
| Other | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 46% |
| Neuroscience | 8 | 29% |
| Medicine and Dentistry | 2 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Psychology | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 3 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2014.
All research outputs
#15,306,466
of 22,764,165 outputs
Outputs from Molecular Brain
#671
of 1,106 outputs
Outputs of similar age
#144,426
of 249,649 outputs
Outputs of similar age from Molecular Brain
#16
of 23 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,649 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.