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Mendeley readers
| Title |
Sustained Pain-Related Depression of Behavior: Effects of Intraplantar Formalin and Complete Freund's Adjuvant on Intracranial Self-Stimulation (ICSS) and Endogenous kappa Opioid Biomarkers in Rats
|
|---|---|
| Published in |
Molecular Pain, January 2014
|
| DOI | 10.1186/1744-8069-10-62 |
| Pubmed ID | |
| Authors |
Michael D Leitl, David N Potter, Kejun Cheng, Kenner C Rice, William A Carlezon, S Stevens Negus |
| Abstract |
Intraplantar administration of complete Freund's adjuvant (CFA) and formalin are two noxious stimuli commonly used to produce sustained pain-related behaviors in rodents for research on neurobiology and treatment of pain. One clinically relevant manifestation of pain is depression of behavior and mood. This study compared effects of intraplantar CFA and formalin on depression of positively reinforced operant behavior in an assay of intracranial self-stimulation (ICSS) in rats. Effects of CFA and formalin on other physiological and behavioral measures, and opioid effects on formalin-induced depression of ICSS, were also examined. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Student > Bachelor | 8 | 16% |
| Researcher | 8 | 16% |
| Other | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 18% |
| Psychology | 8 | 16% |
| Agricultural and Biological Sciences | 6 | 12% |
| Neuroscience | 6 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
| Other | 6 | 12% |
| Unknown | 9 | 18% |