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Multicriteria global optimization for biocircuit design

Overview of attention for article published in BMC Systems Biology, September 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
46 Mendeley
citeulike
3 CiteULike
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Title
Multicriteria global optimization for biocircuit design
Published in
BMC Systems Biology, September 2014
DOI 10.1186/s12918-014-0113-3
Pubmed ID
Authors

Irene Otero-Muras, Julio R Banga

Abstract

BackgroundOne of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple in terms of the number of regulatory regions, and have been designed to meet a single design criterion.ResultsIn this contribution we introduce a multiobjective formulation for the design of biocircuits. We set up the basis for an advanced optimization tool for the modular and systematic design of biocircuits capable of handling high levels of complexity and multiple design criteria. Our methodology combines the efficiency of global Mixed Integer Nonlinear Programming solvers with multiobjective optimization techniques. Through a number of examples we show the capability of the method to generate non intuitive designs with a desired functionality setting up a priori the desired level of complexity.ConclusionsThe methodology presented here can be used for biocircuit design and also to explore and identify different design principles for synthetic gene circuits. The presence of more than one competing objective provides a realistic design setting where every solution represents an optimal trade-off between different criteria.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
Germany 1 2%
Ghana 1 2%
Switzerland 1 2%
Unknown 42 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 35%
Researcher 9 20%
Student > Bachelor 3 7%
Professor > Associate Professor 3 7%
Student > Master 3 7%
Other 4 9%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 20%
Engineering 8 17%
Computer Science 8 17%
Biochemistry, Genetics and Molecular Biology 5 11%
Chemical Engineering 3 7%
Other 4 9%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2014.
All research outputs
#12,560,046
of 21,321,525 outputs
Outputs from BMC Systems Biology
#469
of 1,139 outputs
Outputs of similar age
#103,287
of 224,649 outputs
Outputs of similar age from BMC Systems Biology
#1
of 1 outputs
Altmetric has tracked 21,321,525 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,139 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,649 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them