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Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia

Overview of attention for article published in Fluids and Barriers of the CNS, September 2014
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Title
Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia
Published in
Fluids and Barriers of the CNS, September 2014
DOI 10.1186/2045-8118-11-21
Pubmed ID
Authors

Tavarekere N Nagaraja, Kelly A Keenan, Madhava P Aryal, James R Ewing, Saarang Gopinath, Varun S Nadig, Sukruth Shashikumar, Robert A Knight

Abstract

Limiting expansion of the ischemic core lesion by reinstating blood flow and protecting the penumbral cells is a priority in acute stroke treatment. However, at present, methods are not available for effective drug delivery to the ischemic penumbra. To address these issues this study compared the extravasation and subsequent interstitial spread of a magnetic resonance contrast agent (MRCA) beyond the ischemic core into the surrounding brain in a rat model of ischemia-reperfusion for bolus injection and step-down infusion (SDI) protocols.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Postgraduate 4 17%
Student > Master 3 13%
Student > Ph. D. Student 3 13%
Other 1 4%
Other 3 13%
Unknown 3 13%
Readers by discipline Count As %
Medicine and Dentistry 9 38%
Neuroscience 4 17%
Agricultural and Biological Sciences 3 13%
Biochemistry, Genetics and Molecular Biology 2 8%
Social Sciences 2 8%
Other 2 8%
Unknown 2 8%