Title |
Should we stop prescribing metoclopramide as a prokinetic drug in critically ill patients?
|
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Published in |
Critical Care, September 2014
|
DOI | 10.1186/s13054-014-0502-4 |
Pubmed ID | |
Authors |
Y Gert van der Meer, Willem A Venhuizen, Daren K Heyland, Arthur RH van Zanten |
Abstract |
Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order to minimise the risk of neurological and other adverse reactions associated with the use of metoclopramide. In the ICU, off-label prescription of metoclopramide is common. We have reviewed the evidence for safety, effectiveness and dosing of metoclopramide in critically ill patients. Furthermore, tachyphylaxis is addressed and alternatives are summarised. Finally, recommendations are presented not to abandon use of metoclopramide in ICU patients, because metoclopramide is considered effective in enhancing gastric emptying and facilitating early enteral nutrition. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 18% |
Costa Rica | 2 | 18% |
Greece | 1 | 9% |
Spain | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 55% |
Science communicators (journalists, bloggers, editors) | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 1% |
Unknown | 83 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 14% |
Student > Master | 11 | 13% |
Student > Bachelor | 11 | 13% |
Other | 9 | 11% |
Student > Postgraduate | 7 | 8% |
Other | 13 | 15% |
Unknown | 21 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 43% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 18% |
Chemistry | 3 | 4% |
Arts and Humanities | 2 | 2% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 6 | 7% |
Unknown | 20 | 24% |