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Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification

Overview of attention for article published in BMC Cardiovascular Disorders, March 2014
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Title
Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification
Published in
BMC Cardiovascular Disorders, March 2014
DOI 10.1186/1471-2261-14-29
Pubmed ID
Authors

Karien J Rodriguez, Laura M Piechura, Ana M Porras, Kristyn S Masters

Abstract

Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen attenuates the responsiveness of VICs to pro-calcific stimuli. The current study uses whole leaflet cultures to examine the contributions of endogenous collagen in regulating the phenotype and calcification of VICs.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Canada 1 1%
Unknown 87 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 22%
Student > Master 13 14%
Researcher 10 11%
Student > Bachelor 9 10%
Professor > Associate Professor 6 7%
Other 18 20%
Unknown 14 16%
Readers by discipline Count As %
Engineering 22 24%
Medicine and Dentistry 18 20%
Agricultural and Biological Sciences 13 14%
Biochemistry, Genetics and Molecular Biology 8 9%
Materials Science 3 3%
Other 6 7%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2014.
All research outputs
#18,379,018
of 22,764,165 outputs
Outputs from BMC Cardiovascular Disorders
#1,104
of 1,604 outputs
Outputs of similar age
#161,573
of 222,179 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#16
of 22 outputs
Altmetric has tracked 22,764,165 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,604 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,179 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.