Title |
Role of vitamin D3 in Treatment of Lumbar Disc Herniation—Pain and Sensory Aspects: Study Protocol for a Randomized Controlled Trial
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Published in |
Trials, September 2014
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DOI | 10.1186/1745-6215-15-373 |
Pubmed ID | |
Authors |
Mahsa Sedighi, Ali Haghnegahdar |
Abstract |
Vitamin D receptors have been identified in the spinal cord, nerve roots, dorsal root ganglia and glial cells, and its genetic polymorphism association with the development of lumbar disc degeneration and herniation has been documented. Metabolic effects of active vitamin D metabolites in the nucleus pulposus and annulus fibrosus cells have been studied. Lumbar disc herniation is a process that involves immune and inflammatory cells and processes that are targets for immune regulatory actions of vitamin D as a neurosteroid hormone. In addition to vitamin D's immune modulatory properties, its receptors have been identified in skeletal muscles. It also affects sensory neurons to modulate pain. In this study, we aim to study the role of vitamin D3 in discogenic pain and related sensory deficits. Additionally, we will address how post-treatment 25-hydroxy vitamin D3 level influences pain and sensory deficits severity. The cut-off value for serum 25-hydroxy vitamin D3 that would be efficacious in improving pain and sensory deficits in lumbar disc herniation will also be studied. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 106 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 17 | 16% |
Student > Bachelor | 13 | 12% |
Researcher | 11 | 10% |
Student > Doctoral Student | 9 | 8% |
Student > Ph. D. Student | 9 | 8% |
Other | 18 | 17% |
Unknown | 29 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 33% |
Nursing and Health Professions | 12 | 11% |
Agricultural and Biological Sciences | 7 | 7% |
Neuroscience | 3 | 3% |
Psychology | 2 | 2% |
Other | 11 | 10% |
Unknown | 36 | 34% |