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A practical exact maximum compatibility algorithm for reconstruction of recent evolutionary history

Overview of attention for article published in BMC Bioinformatics, February 2017
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Title
A practical exact maximum compatibility algorithm for reconstruction of recent evolutionary history
Published in
BMC Bioinformatics, February 2017
DOI 10.1186/s12859-017-1520-4
Pubmed ID
Authors

Joshua L. Cherry

Abstract

Maximum compatibility is a method of phylogenetic reconstruction that is seldom applied to molecular sequences. It may be ideal for certain applications, such as reconstructing phylogenies of closely-related bacteria on the basis of whole-genome sequencing. Here I present an algorithm that rapidly computes phylogenies according to a compatibility criterion. Although based on solutions to the maximum clique problem, this algorithm deals properly with ambiguities in the data. The algorithm is applied to bacterial data sets containing up to nearly 2000 genomes with several thousand variable nucleotide sites. Run times are several seconds or less. Computational experiments show that maximum compatibility is less sensitive than maximum parsimony to the inclusion of nucleotide data that, though derived from actual sequence reads, has been identified as likely to be misleading. Maximum compatibility is a useful tool for certain phylogenetic problems, such as inferring the relationships among closely-related bacteria from whole-genome sequence data. The algorithm presented here rapidly solves fairly large problems of this type, and provides robustness against misleading characters than can pollute large-scale sequencing data.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 33%
Researcher 8 19%
Student > Ph. D. Student 4 10%
Professor 4 10%
Student > Bachelor 3 7%
Other 3 7%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 31%
Biochemistry, Genetics and Molecular Biology 12 29%
Computer Science 4 10%
Veterinary Science and Veterinary Medicine 2 5%
Immunology and Microbiology 2 5%
Other 3 7%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2017.
All research outputs
#20,449,496
of 23,005,189 outputs
Outputs from BMC Bioinformatics
#6,887
of 7,312 outputs
Outputs of similar age
#271,205
of 311,218 outputs
Outputs of similar age from BMC Bioinformatics
#120
of 139 outputs
Altmetric has tracked 23,005,189 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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