Title |
Transcriptome sequencing and analysis of Plasmodium gallinaceum reveals polymorphisms and selection on the apical membrane antigen-1
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Published in |
Malaria Journal, September 2014
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DOI | 10.1186/1475-2875-13-382 |
Pubmed ID | |
Authors |
Elvin J Lauron, Khouanchy S Oakgrove, Lisa A Tell, Kevin Biskar, Scott W Roy, Ravinder NM Sehgal |
Abstract |
Plasmodium erythrocyte invasion genes play a key role in malaria parasite transmission, host-specificity and immuno-evasion. However, the evolution of the genes responsible remains understudied. Investigating these genes in avian malaria parasites, where diversity is particularly high, offers new insights into the processes that confer malaria pathogenesis. These parasites can pose a significant threat to birds and since birds play crucial ecological roles they serve as important models for disease dynamics. Comprehensive knowledge of the genetic factors involved in avian malaria parasite invasion is lacking and has been hampered by difficulties in obtaining nuclear data from avian malaria parasites. Thus the first Illumina-based de novo transcriptome sequencing and analysis of the chicken parasite Plasmodium gallinaceum was performed to assess the evolution of essential Plasmodium genes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Lithuania | 1 | 2% |
Unknown | 54 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 30% |
Student > Master | 9 | 16% |
Researcher | 6 | 11% |
Student > Bachelor | 6 | 11% |
Student > Postgraduate | 3 | 5% |
Other | 9 | 16% |
Unknown | 7 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 53% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Immunology and Microbiology | 5 | 9% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Other | 3 | 5% |
Unknown | 8 | 14% |