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An assessment of the impact of host polymorphisms on Plasmodium falciparum vargene expression patterns among Kenyan children

Overview of attention for article published in BMC Infectious Diseases, September 2014
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Title
An assessment of the impact of host polymorphisms on Plasmodium falciparum vargene expression patterns among Kenyan children
Published in
BMC Infectious Diseases, September 2014
DOI 10.1186/1471-2334-14-524
Pubmed ID
Authors

George M Warimwe, Gregory Fegan, Esther W Kiragu, Jennifer N Musyoki, Alexander W Macharia, Kevin Marsh, Thomas N Williams, Peter C Bull

Abstract

Host genotype accounts for a component of the variability in susceptibility to childhood Plasmodium falciparum malaria. However, despite numerous examples of host polymorphisms associated with tolerance or resistance to infection, direct evidence for an impact of host genetic polymorphisms on the in vivo parasite population is difficult to obtain. Parasite molecules whose expression is most likely to be associated with such adaptation are those that are directly involved in the host-parasite interaction. A prime candidate is the family of parasite var gene-encoded molecules on P. falciparum-infected erythrocytes, PfEMP1, which binds various host molecules and facilitates parasite sequestration in host tissues to avoid clearance by the spleen.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Kenya 2 4%
Denmark 1 2%
Unknown 46 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 24%
Student > Ph. D. Student 11 22%
Researcher 8 16%
Student > Doctoral Student 3 6%
Student > Postgraduate 2 4%
Other 8 16%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 35%
Biochemistry, Genetics and Molecular Biology 9 18%
Medicine and Dentistry 8 16%
Mathematics 2 4%
Computer Science 2 4%
Other 6 12%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2014.
All research outputs
#16,099,609
of 23,881,329 outputs
Outputs from BMC Infectious Diseases
#4,648
of 7,931 outputs
Outputs of similar age
#149,923
of 255,004 outputs
Outputs of similar age from BMC Infectious Diseases
#96
of 160 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,931 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,004 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 160 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.